Rabbit Anti-HA monoclonal antibody, clone TO18-17

Co-simulation strategies using both Abaqus/Explicit and Abaqus/Implicit are investigated for analysing wave propagation in two-dimensional unbounded soil domain. The co-simulation is based on the coupling GC method, allowing for coupling different finite element codes with different time integrators and time-scales depending on the partitions of the domain. Absorbing layers using increasing damping (ALID), based on Rayleigh viscous damping, are considered at the boundary to model the semi-infinite medium. The proposed absorbing region is called hybrid (different time integrators) asynchronous (different time steps) absorbing layers using increasing damping (HA-ALID). Lamb's test and a wave barrier problem are investigated. First, HA-ALID turns out to be more accurate than non-reflective conditions available in Abaqus/Explicit. Second, the critical time step in the domain of interest remains unaffected by the choice of damping characteristics in the HA-ALID, contrary to the case of a full explicit computation. Third, the time steps for the solid barrier and the HA-ALID are not restrained by the CFL condition imposed by the explicit partition for stability reasons. Because of its good accuracy and ability to be realized using only FE Abaqus package, without a third-party software component, this strategy provides a wide range of applications in soil-structure interaction problems.

Oxidized hyaluronic acid cross-linked with adipic acid dihydrazide (oxi-HA/ADH) forms an injectable and biocompatible hydrogel suitable for treatment of musculoskeletal diseases and for drug delivery applications. that sense, nanoporous silicon (nPSi) can be combined with biopolymers, such as oxi-HA/ADH hydrogel, to display new characteristics, which are not exhibited by the individual constituents alone. Under this context, this work nPSi microparticles at concentrations from 0.1% to 1% m/v were embedded into oxi-HA/ADH hydrogel to improve its mechanical stability and enhance its control over drug release kinetics using Rose Bengal (RB) as model drug because its cytotoxic effect in different cancer cell lines and tumors has been previously reported. Our results showed, for both compressive force and stress strength tests, that oxi-HA/ADH hydrogel with 1% nPSi microparticles doubled the values of control samples. Moreover, samples of oxi-HA/ADH with nPSi microparticles improved RB release kinetics control over pure oxi-HA/ADH hydrogel. Finally, the cell viability of nPSi microparticles embedded into oxi-HA/ADH hydrogel was confirmed using fibroblasts.