Specifications
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human Integrin alpha V.
Applications
Application Notes
WB: Use at a concentration of 1 μg/ml. Detects a band of approximately 130 & 148 kDa (predicted molecular weight: 116 kDa).
Target
Alternative Names
ITGAV; integrin, alpha V; CD51; MSK8; VNRA; VTNR; integrin alpha-V; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal antibody L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51);
Product Background
Antigen Description
The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions.
Pathway
Adaptive Immune System; Arrhythmogenic right ventricular cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Cell adhesion molecules (CAMs)
Citations
Publication ()
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COA
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