Specifications
Immunogen
Recombinant fragment, corresponding to a region within C terminal amino acids 722-944 of Human Integrin alpha V (UniProt: P06756).
Applications
Application Notes
WB: 1/500 - 1/3000; IHC-P: 1/100 - 1/1000;
Target
Alternative Names
ITGAV; integrin, alpha V; CD51; MSK8; VNRA; VTNR; integrin alpha-V; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal antibody L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51);
Product Background
Antigen Description
The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions.
Pathway
Adaptive Immune System; Arrhythmogenic right ventricular cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Cell adhesion molecules (CAMs)
Citations
Publication ()
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COA
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