Mouse anti-Human INHBB polyclonal antibody

Species Reactivity

Human

Immunogen

INHBB (NP_002184, 298 a.a. ~ 407 a.a) partial recombinant protein with GST tag. The sequence is GRTNLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQ YRMRGLNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGCA

Conjugate

Alternative Names

INHBB; inhibin, beta B; inhibin beta B chain; Inhibin, beta-2; activin beta-B chain; activin AB beta polypeptide;

Entrez Gene ID

UniProt ID

Antigen Description

The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.

Pathway

AGE/RAGE pathway; Cytokine-cytokine receptor interaction; Glycoprotein hormones; Peptide hormone biosynthesis