This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.
Pathway
Arginine and proline metabolism; Glutathione metabolism; Metabolic pathways; Metabolism; Metabolism of amino acids and derivatives; Metabolism of polyamines; Polyamine biosynthesis, arginine => ornithine => putrescine; Regulation of ornithine decarboxylase (ODC); Urea cycle and metabolism of amino groups; Validated targets of C-MYC transcriptional activation; putrescine biosynthesis III; superpathway of polyamine biosynthesis II
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