The Low-Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor types for the neurotrophins, a family of protein growth factors that stimulate neuronal cells to survive and differentiate. The precise function of the LNGFR is somewhat controversial, in contrast to the function of the high-affinity receptor family for the neurotrophins, the Trk receptor tyrosine kinases such as TrkA.
Pathway
Axonal growth inhibition (RHOA activation); Axonal growth stimulation; Cell death signalling via NRAGE; Ceramide signalling; Cytokine-cytokine receptor interaction; NADE modulates death signalling; NF-kB is activated and signals survival; NRAGE signals de
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