Immunoglobulin E (IgE) is a class of antibody (or immunoglobulin "isotype") that has been found only in mammals. IgE is a monomeric antibody with 4 Ig-like domains (Cε1-Cε4). Its main function is immunity to parasites such as parasitic worms like Schistosoma mansoni, Trichinella spiralis, and Fasciola hepatica, and may be important during immune defense against certain protozoan parasites such as Plasmodium falciparum. It also plays an essential role in the allergy disorder, and is especially associated with type I hypersensitivity.
Pathway
Fc-epsilon receptor I signaling in mast cells; IL4-mediated signaling events
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