Cyclooxygenase (COX) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: the conversion of arachidonic acid to PGH2. Recent discoveries of the induction of COX biosynthesis by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of cyclooxygenase, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions. COX-2 is a 72 kDa protein which has been cloned from a variety of species including human, mouse, rat, and sheep.
Pathway
Arachidonic acid metabolism; Biological oxidations; C-MYB transcription factor network; COX reactions; Calcineurin-regulated NFAT-dependent transcription in lymphocytes; Calcium signaling in the CD4+ TCR pathway; Eicosanoid Synthesis; Leishmaniasis; Metab
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