Anti-GJA1 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide

Conjugate

Alternative Names

GJA1; gap junction protein, alpha 1, 43kDa; HSS; CX43; GJAL; ODDD; AVSD3; DFNB38; gap junction alpha-1 protein; connexin 43; connexin-43; gap junction 43 kDa heart protein; SDTY3; ODD; gap junction protein, alpha 1, 43kDa (connexin 43); gap junction prote

Entrez Gene ID

UniProt ID

Antigen Description

Connexin 43 (Cx43) is a widely expressed gap junction protein that mediates communication between many cell types. Gap junctions are implicated in tissue homeostasis and control of cell proliferation and differentiation. Connexin 43 is predominantly localized at the sarcolemma, where six connexins assemble into a so-called connexon or hemichannel. Clusters of these channels assemble to make gap junctions. Cx43 is a target protein of several kinases, among them PKA, PKC, PKG, MAPK, and casein kinase, but also for protein phosphatases. The phosphor- rylation of Cx43 at Ser368 by PKC induces a closure of Hemichannels. Src can phosphorylate Cx43 to alter gap junction communication.

Pathway

Arrhythmogenic right ventricular cardiomyopathy (ARVC); Calcium Regulation in the Cardiac Cell; EGFR1 Signaling Pathway; Formation of annular gap junctions; Gap junction; Gap junction assembly; Gap junction degradation; Gap junction trafficking; Gap junction trafficking and regulation; Membrane Trafficking; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Myometrial Relaxation and Contraction Pathways; N-cadherin signaling events; Regulation of gap junction activ.