Anti-CASP6 monoclonal antibody (DMAB5479MH)

Mouse anti-Human CASP6 monoclonal antibody for IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
7DTQ04
Species Reactivity
Human
Immunogen
BALB/C mice were immunized with recombinant human Caspase 6 prodomain.
Conjugate
Unconjugated

Target


Alternative Names
CASP6; MCH2; caspase 6, apoptosis-related cysteine peptidase; EC 3.4.22; OTTHUMP00000162742; OTTHUMP00000162743
Entrez Gene ID
UniProt ID

Product Background


Pathway
Apoptosis; Apoptosis Modulation by HSP70; Apoptotic cleavage of cellular proteins; Apoptotic execution phase; Breakdown of the nuclear lamina; C-MYB transcription factor network; Caspase cascade in apoptosis; Caspase-mediated cleavage of cytoskeletal prot

Citations


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References


Berta, T; Park, CK; et al. Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-alpha secretion. JOURNAL OF CLINICAL INVESTIGATION 124:1173-1186(2014).
Ren, JL; Meng, YL; et al. The effect of direct translocation across endosomes on the cytotoxicity of the recombinant protein e23sFv-Fdt-casp6 to HER2 positive gastric cancer cells. BIOMATERIALS 32:7641-7650(2011).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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