Anti-CASP6 monoclonal antibody (DMAB5479MH)

Mouse anti-Human CASP6 monoclonal antibody for IHC Datasheet

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Host Species
Antibody Isotype
Species Reactivity
BALB/C mice were immunized with recombinant human Caspase 6 prodomain.


Alternative Names
CASP6; MCH2; caspase 6, apoptosis-related cysteine peptidase; EC 3.4.22; OTTHUMP00000162742; OTTHUMP00000162743
Entrez Gene ID
UniProt ID

Product Background

Apoptosis; Apoptosis Modulation by HSP70; Apoptotic cleavage of cellular proteins; Apoptotic execution phase; Breakdown of the nuclear lamina; C-MYB transcription factor network; Caspase cascade in apoptosis; Caspase-mediated cleavage of cytoskeletal prot


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Vigneswara, V; Akpan, N; et al. Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling. BRAIN 137:1656-1675(2014).
Berta, T; Park, CK; et al. Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-alpha secretion. JOURNAL OF CLINICAL INVESTIGATION 124:1173-1186(2014).

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