Anti-Human ALK monoclonal antibody (DMAB5555RH)

Rabbit Anti-Human ALK monoclonal antibody for IHC-P Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
TQ9
Species Reactivity
Human
Immunogen
Recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript.
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution:
IHC-P: 1:100
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Immunohistochemical analysis of ALK/p80 using anti-ALK/p80 Monoclonal Antibody in Anaplastic Lymphoma. The recommened dilution for this antibody in immunohistochemistry applications is 1:100.

Target


Alternative Names
ALK; anaplastic lymphoma receptor tyrosine kinase; CD246; NBLST3; ALK tyrosine kinase receptor; CD246 antigen

Citations


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References


Wilson, FH; Johannessen, CM; et al. A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer. CANCER CELL 27:397-408(2015).
Zou, HLY; Li, QH; et al. PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:3493-3498(2015).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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