Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human Histone H3, tri methylated at K4.
Applications
Application Notes
Flow Cyt: 1μg/106 cells; WB: 1 - 5 μg/ml; ICC/IF: 5 μg/ml; ChIP: 2-5 μg/25 μg chromatin.
Target
Alternative Names
HIST1H3A; histone cluster 1, H3a; H3/A; H3FA; histone H3.1; histone H3/a; histone 1, H3a; H3 histone family, member A;
Product Background
Antigen Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Pathway
Amyloids, organism-specific biosystem; Disease, organism-specific biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Gene Expression, organism-specific biosystem; Hemostasis, organism-specific biosystem; Meiosis, organism-specific biosystem; Meiotic Recombination, organism-specific biosystem;
Citations
Publication ()
Have you cited DCABH-1297 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
