Anti-HIST1H3A monoclonal antibody, clone BI4-231

Antibody Isotype

IgG1

Clone

BI4-231

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to Histone H3 aa 7-20 (N terminal). aa 7 to 20 and Ac-Lys9.

Conjugate

Alternative Names

HIST1H3A; histone cluster 1, H3a; H3/A; H3FA; histone H3.1; histone H3/a; histone 1, H3a; H3 histone family, member A;

Entrez Gene ID

UniProt ID

Antigen Description

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Pathway

Amyloids, organism-specific biosystem; Disease, organism-specific biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Gene Expression, organism-specific biosystem; Hemostasis, organism-specific biosystem; Meiosis, organism-specific biosystem; Meiotic Recombination, organism-specific biosystem;