Anti-HDAC1 monoclonal antibody, clone 2.U.0

Antibody Isotype

IgG

Clone

2.U.0

Species Reactivity

Mouse; Cow; Human; African green monkey

Immunogen

Synthetic peptide: CEEKPEAKGVKEEVKLA conjugated to KLH, corresponding to amino acids 467-482 of Mouse HDAC1

Conjugate

Application Notes

WB: 0.1 - 1 μg/ml; IHC-FoFr: 1/1000.

Alternative Names

HDAC2; histone deacetylase 2; HD2; RPD3; YAF1; YY1-associated factor 1; transcriptional regulator homolog RPD3;

Entrez Gene ID

UniProt ID

Antigen Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates Lys-310 in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.

Pathway

Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem;