Anti-FLT1 polyclonal antibody [Biotin]

Antibody Isotype

IgG

Species Reactivity

Mouse

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse VEGF R1/Flt-1. Ser27-Glu759 Accession Number P35969

Conjugate

Application Notes

Western Blot 0.1 μg/mL; Flow Cytometry 2.5 μg/10⁶ cells; ELISA Capture 0.2-0.8 μg/mL; ELISA Detection 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DPABY-285 - DPABY-576

Alternative Names

FLT1; FMS-like tyrosine kinase 1; Flt-1; sFlt1; VEGFR1; VEGFR-1; AI323757; vascular endothelial growth factor receptor 1; embryonic receptor kinase 2; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor; vascular endothelial growth

Entrez Gene ID

UniProt ID

Antigen Description

VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.

Pathway

Cytokine-cytokine receptor interaction; Endocytosis; Focal Adhesion; Focal adhesion; HIF-1 signaling pathway; Id Signaling Pathway; Neurophilin interactions with VEGF and VEGFR; PI3K-Akt signaling pathway;