Soluble fms-like tyrosine kinase-1 (sFlt-1 or sVEGFR-1) is a tyrosine kinase protein with antiangiogenic properties. A non-membrane associated splice variant of VEGF receptor 1 (Flt-1), sFlt-1 binds the angiogenic factors VEGF (vascular endothelial growth factor) and PlGF (placental growth factor), reducing blood vessel growth through reduction of free VEGF and PlGF concentrations.
Q: Is this product the full-length sFlt-1, and can you confirm the sequence and molecular weight?
A: This is not the full-length sFlt-1 protein. The product corresponds to a truncated form comprising amino acids 27–327, which accounts for the reported molecular weight of approximately 34 kDa.
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