Anti-FABP2 monoclonal antibody, clone 434840

Antibody Isotype

IgG1

Clone

434840

Species Reactivity

Human

Immunogen

E. coli-derived recombinant human FABP2/I-FABP. Ala2-Asp132 Accession Number P12104

Conjugate

Application Notes

ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4201 - DPABY-531

Alternative Names

FABP2; fatty acid binding protein 2, intestinal; FABPI; I-FABP; fatty acid-binding protein, intestinal; fatty acid-binding protein 2; intestinal-type fatty acid-binding protein;

Entrez Gene ID

UniProt ID

P12104

Antigen Description

Fatty acid binding proteins are small cytoplasmic lipid binding proteins that are expressed in a tissue specific manner. FABPs bind free fatty acids, cholesterol, and retinoids, and are involved in intracellular lipid transport. Circulating FABP levels are used as indicators of tissue damage. Some FABP polymorphisms have been associated with disorders of lipid metabolism and the development of atherosclerosis.FABP2, also known as intestinal fatty acid binding protein (I-FABP or FABPI) and gut FABP (gFABP), is a member of the cytosolic fatty acid binding protein family. FABP2 mediates the absorption and intracellular transport of dietary long-chain fatty acids. Genetic variations of FABP2 are implicated in obesity and Type II diabetes. Human FABP2 shares 78%, 82%, and 86% amino acid sequence identity with mouse, rat, and canine FABP2, respectively.

Pathway

Fat digestion and absorption; PPAR signaling pathway;