Anti-Human DNTT monoclonal antibody

Air-stable organic thin-film transistors (OTFTs) for active matrix (AM) displays are developed with dinaphtho[2,3-b:2',3'-f]thieno[3,2-b]thiophene (DNTT), which is a recently emerging organic semiconductor material. Compared to commonly used pentacene with the HOMO level of -5.0 eV, the deeper HOMO level of DNTT (-5.4 eV) renders it much more stable in air. Here, we demonstrate the first operation of the DNTT-TFT driven liquid crystal display (LCD).

MicroRNA-125b (miR-125b), miR-99a and miR-100 are overexpressed in vincristine-resistant acute lymphoblastic leukemia (ALL). Cellular viability of ETV6-RUNX1-positive Reh cells significantly increased in presence of 9 ng/mL vincristine upon co-expression of miR-125b/miR-99a (91 +/- 4%), miR-125b/miR-100 (93 +/- 5%) or miR-125b/miR-99a/miR-100 (82 +/- 17%) compared with miR-125b-transduced cells (38 +/- 13%, P < 0.05). Co-expression of these miRNAs resulted in downregulation of DNTT, NUCKS1, MALAT1, SNRPE, PNO1, SET, KIF5B, PRPS2, RPS11, RPL38 and RPL23A (fold-change 1.3-1.9, p < 0.05). Similarly, 7 out of these genes are lower expressed in vincristine-resistant ALL cells of children (p < 0.05). The concerted function of miR-125b in combination with miR-99a and/or miR-100 illustrates the complexity of vincristine-resistant pediatric ALL. (C) 2013 Elsevier Ltd. All rights reserved.