Organic Active-matrix TFTs with Air-Stable Organic Semiconductors
IDW'11: PROCEEDINGS OF THE 18TH INTERNATIONAL DISPLAY WORKSHOPS, VOLS 1-3
Authors: Uemura, Takafumi; Uno, Mayumi; Nakayama, Kengo; Shomoto, Norikazu; Itoh, Masataka; Takimiya, Kazuo; Takeya, Jun
Abstract
Air-stable organic thin-film transistors (OTFTs) for active matrix (AM) displays are developed with dinaphtho[2,3-b:2',3'-f]thieno[3,2-b]thiophene (DNTT), which is a recently emerging organic semiconductor material. Compared to commonly used pentacene with the HOMO level of -5.0 eV, the deeper HOMO level of DNTT (-5.4 eV) renders it much more stable in air. Here, we demonstrate the first operation of the DNTT-TFT driven liquid crystal display (LCD).
MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia
LEUKEMIA RESEARCH
Authors: Moqadam, F. Akbari; Lange-Turenhout, E. A. M.; Aries, I. M.; Pieters, R.; den Boer, M. L.
Abstract
MicroRNA-125b (miR-125b), miR-99a and miR-100 are overexpressed in vincristine-resistant acute lymphoblastic leukemia (ALL). Cellular viability of ETV6-RUNX1-positive Reh cells significantly increased in presence of 9 ng/mL vincristine upon co-expression of miR-125b/miR-99a (91 +/- 4%), miR-125b/miR-100 (93 +/- 5%) or miR-125b/miR-99a/miR-100 (82 +/- 17%) compared with miR-125b-transduced cells (38 +/- 13%, P < 0.05). Co-expression of these miRNAs resulted in downregulation of DNTT, NUCKS1, MALAT1, SNRPE, PNO1, SET, KIF5B, PRPS2, RPS11, RPL38 and RPL23A (fold-change 1.3-1.9, p < 0.05). Similarly, 7 out of these genes are lower expressed in vincristine-resistant ALL cells of children (p < 0.05). The concerted function of miR-125b in combination with miR-99a and/or miR-100 illustrates the complexity of vincristine-resistant pediatric ALL. (C) 2013 Elsevier Ltd. All rights reserved.
COA
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