Rabbit Anti-Human DNTT (internal) Polyclonal antibody

Name: Rabbit Anti-Human DNTT (internal) Polyclonal antibody
SKU: DPABH-22131
Rating: 5 (1 reviews)

Rabbit Anti-Human DNTT (internal) Polyclonal antibody for WB, IF/ICC

COA

SDS

Datasheet

Key features and details

Specificity: DNTT Antibody detects endogenous levels of total DNTT.
Host: Rabbit
Application: WB, IF/ICC
Species Reactivity: Human; Predicted: Mouse

Summary

Specifications

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthesized peptide derived from human DNTT, corresponding to a region within the internal amino acids.

Conjugate

Unconjugated

Applications

Application Notes

WB 1:500-1:1000
IF/ICC 1:100-1:500

General Notes

This product (Catalog No. DPABH-22131) is a rabbit-derived polyclonal antibody raised against human DNTT. It has been affinity purified by Protein A. The terminal deoxynucleotidyl transferase (Terminal deoxynucleotidyl transferase, tdT) is a template independent DNA polymerase belonging to the family of DNA polymerases X. TdT allows for the indiscriminate addition of deoxynucleotide monomers to the 3' -OH end of single-stranded (ssDNA) or double-stranded DNA (dsDNA) to continuously extend the DNA strand, and the extension reaction does not require templates, a feature that makes it of great research value and application prospect. TdT begins to express at the earliest stage of B, T cell differentiation and plays an important role in the development, progression and response of the associated cancer. In recent years, tdT has been rapidly studied as an anticancer target. TdT is an intracellular marker of strong specificity for immature lymphocytes in the hematopoietic system, expressed in pre-T and pre-B cells and in multipotent stem cells of thymus and bone marrow, strongly expressed in pre-B and pre-T lymphoblastic lymphomas, and usually negative in mature T, B cell tumors, and therefore TdT becomes a very valuable indicator for pathological diagnosis of thymoma and T, B lymphoblastic lymphomas. Previous studies have also shown that TdT is expressed positively in Acute Lymphoblastic Leukemia (ALL), negatively in Acute Myeloid Leukemia (AML), and only AML-M0 or AML is accompanied by expression of TdT in multiple dysplasia patients, thus TdT is one of the key markers for identifying ALL and AML. The accurate detection of the expression profile of TdT in pathological samples such as cells, tissues and the like is significant for clinical diagnosis of the diseases. In addition, many biological roles of TdT have not been fully revealed, and functional studies of TdT also require accurate localization of TdT expression in cells, tissues.
DPABH-22131 is suitable for use in WB 1 (500-1:1000), IF/ICC 1 (100-1:500) applications.
DPABH-22131 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Target

Entrez Gene ID

1791

UniProt ID

P04053

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

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References

Interface Structure and Evolution of Dinaphthothienothiophene (DNTT) Films on Noble Metal Substrates

ADVANCED MATERIALS INTERFACES

Authors: Dreher, Maximilian; Bischof, Daniel; Widdascheck, Felix; Huttner, Andrea; Breuer, Tobias; Witte, Gregor

Abstract

Dinaphthothienothiophene (DNTT) is a promising new organic semiconductor which combines high charge carrier mobility with chemical robustness. Although the properties of organic electronic devices are largely determined by the interfaces with electrodes, the interface between DNTT and metals is hardly studied so far. Here, the interface structures of DNTT on Ag(111) and multilayers are examined and they are compared with films grown on polycrystalline and (111) surfaces of silver and gold. In the seedlayer regime, two different interface structures formed by exclusively flatlying molecules and a herringbone arrangement are identified for increased coverages. Combining low energy electron diffraction, scanning tunneling microscopy, and X-ray absorption measurements, precise structure data for both phases are derived and their respective adsorption energies are determined to explain why both phases are formed. On all examined surfaces, DNTT multilayers consist of discrete fibers reflecting a notable dewetting but exhibit different molecular orientations: Molecules are recumbently arranged on the (111) surfaces, but uprightly oriented on polycrystalline surfaces. Complementary work function measurements yield rather similar values for DNTT monolayers on single- and polycrystalline metal substrates, while distinct differences are found for thicker films. The results appear important for improved transistor geometries, in particular vertical field-effect transistors.

Thermoelectric transport properties of high mobility organic semiconductors

ORGANIC FIELD-EFFECT TRANSISTORS XV

Authors: Venkateshvaran, Deepak; Broch, Katharina; Warwick, Chris N.; Sirringhaus, Henning

Abstract

Transport in organic semiconductors has traditionally been investigated using measurements of the temperature and gate voltage dependent mobility of charge carriers within the channel of organic field-effect transistors (OFETs). In such measurements, the behavior of charge carrier mobility with temperature and gate voltage, studied together with carrier activation energies, provide a metric to quantify the extent of disorder within these van der Waals bonded materials. In addition to the mobility and activation energy, another potent but often-overlooked transport coefficient useful in understanding disorder is the Seebeck coefficient (also known as thermoelectric power). Fundamentally, the Seebeck coefficient represents the entropy per charge carrier in the solid state, and thus proves powerful in distinguishing materials in which charge carriers move freely from those where a high degree of disorder causes the induced carriers to remain trapped. This paper briefly covers the recent highlights in the field of organic thermoelectrics, showing how significant strides have been made both from an applied standpoint as well as from a viewpoint of fundamental thermoelectric transport physics. It shall be illustrated how thermoelectric transport parameters in organic semiconductors can be tuned over a significant range, and how this tunability facilitates an enhanced performance for heat-to-electricity conversion as well as quantifies energetic disorder and the nature of the density of states (DOS). The work of the authors shall be spotlighted in this context, illustrating how Seebeck coefficient measurements in the polymer indacenodithiophene-co-benzothiadiazole (IDTBT) known for its ultra-low degree of torsion within the polymer backbone, has a trend consistent with low disorder. 1 Finally, using examples of the small molecules C8-BTBT and C10-DNTT, it shall be discussed how the Seebeck coefficient can aid the estimation of the density and distribution of trap states within these materials. (2,3)