Specifications
Immunogen
Full length human recombinant protein of human CYP1A2 produced in HEK293T cell.
Applications
Application Notes
ELISA: 1:250-1:1000
We recommend the following for sandwich ELISA (Capture - Detection):
CABT-ZC1123 - CABT-ZC1121
CABT-ZC1122 - CABT-ZC1121
Target
Alternative Names
CP12; P3-450; P450(PA)
Product Background
Antigen Description
CYP1A2 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3" untranslated region.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Yamada, K; Suzuki, T; et al. Metabolic activation of 10-aza-substitutedbenzo[a]pyrene by cytochrome P450 1A2 in human liver microsomes. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 557:159-165(2004).
LEWIS, AD; LAU, DHM; et al. ROLE OF CYTOCHROME-P-450 FROM THE HUMAN CYP3A GENE FAMILY IN THE POTENTIATION OF MORPHOLINO DOXORUBICIN BY HUMAN LIVER-MICROSOMES. CANCER RESEARCH 52:4379-4384(1992).
COA
Certificate of Analysis
