Anti-CYP1A2 monoclonal antibody, clone 500DU24.3.3

Antibody Isotype

IgG3

Clone

500DU24.3.3

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:500-2000

Alternative Names

CYP1A2; Cytochrome P450 1A2; CYPIA2; Cytochrome P(3)450; Cytochrome P450 4; Cytochrome P450-P3

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.The protein encoded by this gene localizes to the endoplasmicreticulum and its expression is induced by some polycyclic aromatichydrocarbons (PAHs), some of which are found in cigarette smoke.The enzyme's endogenous substrate is unknown; however, it is ableto metabolize some PAHs to carcinogenic intermediates. Otherxenobiotic substrates for this enzyme include caffeine, aflatoxinB1, and acetaminophen. The transcript from this gene contains fourAlu sequences flanked by direct repeats in the 3' untranslatedregion.

Pathway

Aflatoxin B1 metabolism; AhR pathway; Arachidonic acid metabolism; Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2; Arylamine metabolism; Biological oxidations; Caffeine metabolism; Chemical carcinogenesis;