Anti-CXCL2 monoclonal antibody, clone 234903

Antibody Isotype

IgG2b

Clone

234903

Species Reactivity

Rat

Immunogen

E. coli-derived recombinant rat CXCL2/GRO beta/MIP-2/CINC-3. Ser32-Asn100 Accession Number P30348

Conjugate

Application Notes

Western Blot: 1 μg/mL; ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4105 - DPABY-423

Alternative Names

CXCL2; chemokine (C-X-C motif) ligand 2; Mip-2; Scyb2; C-X-C motif chemokine 2; MIP2; CINC-3; macrophage inflammatory protein 2; small inducible cytokine subfamily, member 2; cytokine-induced neutrophil chemoattractant 3;

Entrez Gene ID

UniProt ID

Antigen Description

CXCL2/GRO beta, also called MIP-2 in mouse and CINC-3 in rat, is a member of the CXC chemokine family. Human CXCL2/GRO beta is 107 amino acids (aa) in length with a predicted molecular weight of 11 kDa. The mouse and rat orthologs share 70% and 71% aa sequence identity with the human protein, respectively. N-terminal aa 1-4 of CXCL2/GRO beta can be post-translationally cleaved which confers enhanced hematopoietic bioactivity. CXCL2/GRO beta is produced by a variety of cell types including monocytes and macrophages at sites of inflammation and is chemotactic for granulocytes, including neutrophils.

Pathway

Chemokine receptors bind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-like receptors); Cytokine-cytokine receptor interaction; G alpha (i) signalling events; GPCR downstream signaling; GPCR ligand binding; Legionellosis;