General Notes
This product (Catalog No. DPABH-26846) is a rabbit-derived polyclonal antibody raised against human CTH, targeting the amino acid region 163–382 of the protein. This antibody exhibits cross-reactivity with Human CTH from mouse and rat. It has been affinity purified by Protein A. Cystathionine gamma-lyase (also known as cystathionine γ-lyase or CSE; EC 4.4.1.1) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the irreversible γ-cleavage of L-cystathionine to produce L-cysteine, α-ketobutyrate (2-oxobutyrate), and ammonia in the transsulfuration pathway, enabling the transfer of sulfur from methionine to cysteine biosynthesis. Encoded by the CTH gene located on human chromosome 1p31.1, the enzyme is ubiquitously expressed in mammalian tissues, with highest levels in the liver, kidney, and brain, where it maintains cysteine homeostasis and supports glutathione production for antioxidant defense.
DPABH-26846 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-26846 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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