Perceived cognitive impairment in people with colorectal cancer who do and do not receive chemotherapy
JOURNAL OF CANCER SURVIVORSHIP
Authors: Dhillon, Haryana M.; Tannock, Ian F.; Pond, Gregory R.; Renton, Corrinne; Rourke, Sean B.; Vardy, Janette L.
Cognitive symptoms are common after cancer, but poorly associated with neuropsychological results. We previously reported colorectal cancer (CRC) patients had more cognitive impairment than controls. Here, we explore relationships between cognitive symptoms and neuropsychological domains. Subjects with CRC (N = 362) and 72 healthy controls completed neuropsychological assessments and Functional Assessment of Cancer Therapy-Cognition (FACT-COG) at baseline (pre-chemotherapy) and 6, 12, and 24 months. Associations between neuropsychological and FACT-COG scores were explored: perceived cognitive impairment (PCI), perceived cognitive ability (PCA), impact of PCI on quality of life (CogQOL). Of 362 CRC subjects, 289 had loco-regional disease and 173 received chemotherapy (CTh+). At baseline, groups did not differ on total FACT-COG, PCI, or PCA scores. All scores, except PCA, were worse at 6 months in CTh+. CRC patients not receiving chemotherapy did not differ from controls on FACT-COG domains. PCA associated weakly (r = 0.28-0.34) with attention/executive function, visual memory, and global deficit score. There was no association between PCI and neuropsychological domains. Fatigue, anxiety/depression, and poorer quality of life were associated with PCI and CogQOL (r = 0.44-0.51) in CRC patients. No association was seen between total FACT-COG or PCI, and neuropsychological domains. A weak-moderate association was found between PCA and attention/executive function and visual memory. The study was registered with clinicaltrials. gov (trial registration: NCT00188331). Cognitive symptoms are associated with fatigue, anxiety/depression, and poorer quality of life, and do not appear to be related to actual cognitive performance. Rates were lower than that reported in breast cancer survivors. Cognitive symptoms were greatest in those who received chemotherapy, with no significant difference between the non-chemotherapy survivors and healthy controls.
Energy Security and "Big Stick" Legislation
ENVIRONMENTAL AND PLANNING LAW JOURNAL
Authors: Pan, Kin
Energy security is the central goal of energy policy. It is a multidimensional concept that incorporates notions of adequacy, reliability, affordability and sustainability. However, Australia's ongoing energy crisis, particularly on the country's east and south coast, suggests that Australian energy law has failed to rise to the challenge of achieving energy security at a time when our climate continues to change. In an attempt to improve Australia's energy security, the Commonwealth government has recently turned to "big stick" legislation aimed at curbing energy market misconduct. This article analyses whether the Treasury Laws Amendment (Prohibiting Energy Market Misconduct) Act 2019 (Cth) truly possesses energy security merit, or instead illustrates the government's lack of vision at a critical juncture in energy law.