Human CTH ELISA Matched Antibody Pair (ABPR-0236)

Regulatory status: For research use only, not for use in diagnostic procedures.

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Species Reactivity
Human
Intended Use
This antibody pair set comes with matched antibody pair to detect and quantify protein level of human CTH.
General Description
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms.
Reconstitution And Storage
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.

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References


Neurosurgical Outcomes of Isolated Hemorrhagic Mild Traumatic Brain Injury

CUREUS

Authors: Krueger, Evan M.; Putty, Matthew; Young, Michael; Gaynor, Brandon; Omi, Ellen; Farhat, Hamad

Introduction Mild traumatic brain injury (TBI) is common but its management is variable. Objectives To describe the acute natural history of isolated hemorrhagic mild TBI. Methods This was a single-center, retrospective chart review of 661 patients. Inclusion criteria were consecutive patients with hemorrhagic mild TBI. Exclusion criteria were any other acute traumatic injury and significant comorbidities. Variables recorded included neurosurgical intervention and timing, mortality, emergency room disposition, intensive care unit (ICU) length of stay (LOS), discharge disposition, repeat computed tomography head (CTH) indications and results, neurologic exam, age, sex, Glasgow Coma Scale (GCS) score, and hemorrhage type. Results Overall intervention and unexpected delayed intervention rates were 9.4% and 1.5%, respectively. The mortality rate was 2.4%. A 10-year age increase had 26% greater odds of intervention (95% CI, 9.6-45%; P<.001) and 53% greater odds of mortality (95% CI, 11-110%; P=.009). A one-point GCS increase had 49% lower odds of intervention (95% CI, 25-66%; P<.001) and 50% lower odds of mortality (95% CI, 1-75%; P=.047). Subdural and epidural hemorrhages were more likely to require intervention (P=.02). ICU admission was associated with discharge to an acute care facility (OR, 2.9; 95% CI, 1.4-6.0; P=.003). Neurologic exam changes were associated with a worsened CTH scan (OR, 12.3; 95% CI, 7.0-21.4; P<.001) and intervention (OR, 15.1; 95% CI, 8.4-27.2; P<.001). Conclusions Isolated hemorrhagic mild TBI patients are at a low, but not clinically insignificant, risk of intervention and mortality.

Development of a Soil Quality Index for Soils under Different Agricultural Management Conditions in the Central Lowlands of Mexico: Physicochemical, Biological and Ecophysiological Indicators

SUSTAINABILITY

Authors: Bedolla-Rivera, Hector Ivan; Negrete-Rodriguez, Maria De La Luz Xochilt; Medina-Herrera, Miriam Del Rocio; Gamez-Vazquez, Francisco Paul; Alvarez-Bernal, Dioselina; Samaniego-Hernandez, Midory; Gamez-Vazquez, Alfredo Josue; Conde-Barajas, Eloy

The Bajio-Mexico's central lowlands-is a region of economic importance because of its agricultural industry. Over time, agricultural practices have led to soil deterioration, loss of fertility, and abandonment. In this study, six agricultural soils were analyzed: AGQ, CTH, CTJ, JRM, CRC, and CYI, and used to develop a soil quality index (SQI) that includes the use of physicochemical, biological, and ecophysiological indicators to differentiate soil quality. Principal component analysis (PCA) was used, reducing the indicators from 46 to 4, which represents 80.4% of data variability. It was implemented the equation of additive weights using the variance of the principal components as a weight factor for the SQI. The developed SQI was according to the indicators WHC, SLT, N-NO3-, and qCO(2), differentiating the quality of soils from the agricultural management in low quality (JRM < CYI < AGQ) and moderate quality (CTJ < CRC < CTH). The use of biological and ecophysiological indicators added to the PCA and the equation of additive weights allowed establishing an SQI with a minimum of indicators, sensitive to agricultural management, facilitating its interpretation and implementation for the Mexican Bajio region and soils in similar conditions around the world.

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