Anti-CSE1L (aa 872-971) polyclonal antibody

Species Reactivity

Human; Mouse; Rat

Immunogen

CSE1L (NP_001307, 872 a.a. ~ 971 a.a) partial recombinant protein with GST tag. The sequence is LIGLFELPEDDTIPDEEHFIDIEDTPGYQTAFSQLAFAGKKEHDPVGQMVNNPKIHLAQS LHKLSTACPGRVPSMVSTSLNAEALQYLQGYLQAARVTLL

Conjugate

Alternative Names

CSE1L; CSE1 chromosome segregation 1-like (yeast); CAS; CSE1; XPO2; exportin-2; exp2; importin-alpha re-exporter; chromosome segregation 1-like protein; cellular apoptosis susceptibility protein;

Entrez Gene ID

UniProt ID

Antigen Description

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene.

Pathway

Direct p53 effectors;