Anti-CSE1L monoclonal antibody, clone HU6222

Antibody Isotype

IgG2b

Clone

HU6222

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment within Human Cellular Apoptosis Susceptibility aa 222-469. The exact sequence is proprietary.Database link: P55060

Conjugate

Application Notes

WB: 1/500 - 1/3000;

Alternative Names

CSE1L; CSE1 chromosome segregation 1-like (yeast); chromosome segregation 1 (yeast homolog) like; exportin-2; CAS; CSE1; XPO2; exp2; importin-alpha re-exporter; chromosome segregation 1-like protein; cellular apoptosis susceptibility protein; MGC117283; M

Entrez Gene ID

UniProt ID

Antigen Description

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Pathway

Direct p53 effectors, organism-specific biosystem; p53 pathway, organism-specific biosystem;