Anti-CSE1L monoclonal antibody, clone 41G23

Antibody Isotype

IgG2a

Clone

41G23

Species Reactivity

Human

Immunogen

Prokaryotic recombinant protein, corresponding to an internal region of 342 amino acids from Human Cellular Apoptosis Susceptibility.

Conjugate

Application Notes

WB: 1/25 - 1/50; IHC-P: 1/40 - 1/80; IHC-Fr: 1/40 - 1/80

Alternative Names

CSE1L; CSE1 chromosome segregation 1-like (yeast); chromosome segregation 1 (yeast homolog) like; exportin-2; CAS; CSE1; XPO2; exp2; importin-alpha re-exporter; chromosome segregation 1-like protein; cellular apoptosis susceptibility protein; MGC117283; M

Entrez Gene ID

UniProt ID

Antigen Description

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Pathway

Direct p53 effectors, organism-specific biosystem; p53 pathway, organism-specific biosystem;