Specifications
Immunogen
CNOT4 antibody was raised against a 19 amino acid peptide near the amino terminus of the human CNOT4.
Target
Alternative Names
CNOT4; CCR4-NOT transcription complex, subunit 4; NOT4; NOT4H; CLONE243; CCR4-NOT transcription complex subunit 4; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; potential transcriptional repressor NOT4Hp; NOT4 (negative regulator of transcr
Product Background
Antigen Description
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Pathway
Deadenylation of mRNA; Deadenylation-dependent mRNA decay; Gene Expression; RNA degradation
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Sandler, H; Kreth, J; et al. Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin. NUCLEIC ACIDS RESEARCH 39:4373-4386(2011).
Laribee, RN; Shibata, Y; et al. CCR4/NOT complex associates with the proteasome and regulates histone methylation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104:5836-5841(2007).
COA
Certificate of Analysis
