The protein encoded by this gene is a subunit of theCCR4-NOT complex, a global transcriptional regulator. The encodedprotein interacts with CNOT1 and has E3 ubiquitin ligase activity.Several transcript variants encoding different isoforms have beenfound for this gene.
Pathway
Deadenylation of mRNA; Deadenylation-dependent mRNA decay; Gene Expression; RNA degradation
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Lenssen, E; Azzouz, N; et al. The Ccr4-Not complex regulates Skn7 through Srb10 kinase. EUKARYOTIC CELL 6:2251-2259(2007).
Sandler, H; Kreth, J; et al. Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin. NUCLEIC ACIDS RESEARCH 39:4373-4386(2011).
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COA
Certificate of Analysis
