Tag/Conjugate
Unconjugated
Antigen Description
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Function
ligase activity; nucleotide binding; poly(A) RNA binding; protein binding; ubiquitin-protein transferase activity; zinc ion binding
Synonyms
CNOT4; CCR4-NOT transcription complex, subunit 4; NOT4; NOT4H; CLONE243; CCR4-NOT transcription complex subunit 4; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; potential transcriptional repressor NOT4Hp; NOT4 (negative regulator of transcription 4, yeast) homolog
Citations
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Gaillard, H; Tous, C; et al. Genome-Wide Analysis of Factors Affecting Transcription Elongation and DNA Repair: A New Role for PAF and Ccr4-Not in Transcription-Coupled Repair. PLOS GENETICS 5:-(2009).
Miller, JE; Reese, JC; et al. Ccr4-Not complex: the control freak of eukaryotic cells. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 47:315-333(2012).
COA
Certificate of Analysis
