Anti-CMAS (aa 164-263) polyclonal antibody

Introduction: We explored the use of quantitative muscle ultrasonography (QMUS) for follow-up of juvenile dermatomyositis (JDM). Methods: Seven JDM patients were evaluated at diagnosis and 1, 3, 6, 12, and 24 months using the Childhood Myositis Assessment Scale (CMAS) and QMUS. Muscle thickness (MT) and quantitative muscle echo intensity (EI) were assessed with QMUS in 4 muscles. Results: Six patients experienced a monocyclic course. At diagnosis EI was slightly increased, and MT was relatively normal. After start of treatment MT first decreased and EI increased, with normalization of EI within 6-12 months (n = 4). One patient had higher EIs at diagnosis and slower normalization, indicating fibrosis, despite early normalization of CMAS. One patient experienced a chronic course, with high EIs and atrophy during follow-up. Conclusions: QMUS can provide additional information for follow-up of JDM regarding disease severity and residual muscle damage, particularly after normalization of CMAS.

Hot corrosion is one of the significant failure mechanisms in hot-section components, especially when molten CaO-MgO-Al2O3-SiO2 (CMAS) deposits attack the thermal barrier coating and facilitate its degradation at elevated temperatures. This work concentrates on the hot corrosion behavior of LaMgAl11O19 ceramic as a promising candidate for TBCs after exposure to CMAS at 1250 degrees C for 1-16 h in air. The phase constituents and morphologies of the hot corrosion products were investigated by X-ray diffraction and scanning electron microscopy, respectively. Energy-dispersive X-ray spectroscopy was employed for elemental and microstructure analysis. The corrosion products are identified to be CaAl2Si2O8 and Ca(Mg,Al)(Al,Si)(2)O-6 due to the interaction between LaMgAl11O19 ceramic and melt-CMAS by dissolution-reprecipitation. The hot corrosion mechanism was further proposed based on the phase diagram. (C) 2016 Elsevier B.V. All rights reserved.