Anti-CKB monoclonal antibody, clone DL-21

Name: Anti-CKB monoclonal antibody, clone DL-21
SKU: DCABH-5
Rating: 5 (1 reviews)

Mouse anti-Human CKB monoclonal antibody for ELISA

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG

Clone

DL-21

Species Reactivity

Human

Immunogen

These clones have been derived from hybridization of Sp 2/0 myeloma cells with spleen cells of Balb/c mice immunized with human creatine kinase MB.

Conjugate

Unconjugated

Target

Alternative Names

CKB; creatine kinase, brain; creatine kinase B-type; creatine kinase B chain; Bck; Ck3; B-CK; Ck-3; Ckbb;

Entrez Gene ID

12709

UniProt ID

Q04447

Product Background

Antigen Description

Creatine Kinase MB consists of a dimer of nonidentical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain. Creatine Kinase MB reversibly catalyses the transfer of phosphate between ATP and various phosphogens. The creatine kinase isoenzymes play a central role in energy transduction in tissues with large fluctuating energy demands such as skeletal muscle, heart, brain and spermatozoa.

Pathway

Arginine and proline metabolism, organism-specific biosystem; Arginine and proline metabolism, conserved biosystem; Creatine metabolism, organism-specific biosystem; Creatine pathway, organism-specific biosystem; Creatine pathway, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem;

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

A model of collaborative knowledge-building based on Web2.0

RESEARCH AND PRACTICAL ISSUES OF ENTERPRISE INFORMATION SYSTEMS II, VOL 2

Authors: Wang, Rong; Fang, Meiqi; Chen, Yu

Abstract

The ubiquitous linking of computers in local and global networks makes possible the sharing of thoughts by people who are separated spatially or temporally. Many efforts are made to increase opportunities for effective collaborative working, learning and acting through innovative uses of computer technology, and one of these efforts is to build group knowledge collaboratively. This paper presents a model of collaborative knowledge-building (CKB) as a social process, which constitutes both personal and social knowledge-building as well as aggregations between them. This model incorporates insights from Web 2.0, CAS and CSCL (Computer Support of Collaborative of Learning) in the hope of providing a useful conceptual framework for the design of collaborative knowledge-building environments.

Quantitative Proteomic Study of Human Lung Squamous Carcinoma and Normal Bronchial Epithelial Acquired by Laser Capture Microdissection

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Authors: Xu Yan; Cao Lan-Qin; Jin Long-Yu; Chen Zhu-Chu; Zeng Gu-Qing; Tang Can-E; Li Guo-Qing; Duan Chao-Jun; Peng Fang; Xiao Zhi-Qiang; Li Cui

Abstract

Objective. To investigate the differential protein profile of human lung squamous carcinoma (HLSC) and normal bronchial epithelium (NBE) and provide preliminary results for further study to explore the carcinogenic mechanism of HLSC. Methods. Laser capture microdissection (LCM) was used to purify the target cells from 10 pairs of HLSC tissues and their matched NHBE, respectively. A stable-isotope labeled strategy using iTRAQ, followed by 2D-LC/Q-STAR mass spectrometry, was performed to separate and identify the differential expression proteins. Results. A total of 96 differential expression proteins in the LCM-purified HLSC and NBE were identified. Compared with NBE, 49 proteins were upregulated and 47 proteins were downregulated in HLSC. Furthermore, the expression levels of the differential proteins including HSPB1, CKB, SCCA1, S100A8, as well as S100A9 were confirmed by western blot and tissue microarray and were consistent with the results of quantitative proteomics. Conclusion. The different expression proteins in HLSC will provide scientific foundation for further study to explore the carcinogenic mechanism of HLSC.