Synthetic peptide, with a Cysteine residue linker, corresponding to internal sequence amino acids 436-446 of Human Nicotinic Acetylcholine Receptor epsilon (NP_000071.1).
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Pathway
Acetylcholine Binding And Downstream Events; ErbB2/ErbB3 signaling events; Neuroactive ligand-receptor interaction; Neuronal System
Citations
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