Anti-CHRNE (aa 21-130) polyclonal antibody

Species Reactivity

Human

Immunogen

CHRNE (NP_000071, 21 a.a. ~ 130 a.a) partial recombinant protein with GST tag. The sequence is KNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDW QDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLV

Conjugate

Alternative Names

CHRNE; cholinergic receptor, nicotinic, epsilon (muscle); ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS; acetylcholine receptor subunit epsilon; AchR epsilon subunit; acetylcholine receptor, nicotinic, epsilon (muscle); cholinergic receptor, nicotinic, epsilon

Entrez Gene ID

UniProt ID

Antigen Description

Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome.

Pathway

Acetylcholine Binding And Downstream Events; ErbB2/ErbB3 signaling events; Neuroactive ligand-receptor interaction; Neuronal System