Anti-CHEK2 monoclonal antibody, clone FQS6639 Knockout Validated

Name: Anti-CHEK2 monoclonal antibody, clone FQS6639
SKU: DCABH-2748

Rabbit anti-Human CHEK2 monoclonal antibody for WB

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG

Clone

FQS6639

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to residues in the N-terminal of Human Chk2

Conjugate

Unconjugated

Target

Alternative Names

CHEK2; checkpoint kinase 2; CHK2 (checkpoint, S.pombe) homolog , CHK2 checkpoint homolog (S. pombe) , RAD53; serine/threonine-protein kinase Chk2; bA444G7; CDS1; CHK2; HuCds1; PP1425; cds1 homolog; CHK2 checkpoint homolog; checkpoint-like protein CHK2; L

Entrez Gene ID

11200

UniProt ID

O96017

Product Background

Antigen Description

Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on Ser-216, preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at Thr-18 and Ser-20.

Pathway

Cell Cycle, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; FOXM1 transcription factor network, organism-specific biosystem; G1/S DNA Damage Checkpoints, organism-specific biosystem;

Citations