Specifications
Species Reactivity
Rat; Dog; Human; Monkey
Immunogen
Recombinant full length Human Chk2 protein produced in HEK293T cells (NP_009125).
Applications
Application Notes
WB: 1/500 - 1/1000; Flow Cyt: 1/100; ICC/IF: 1/50 - 1/100;
Target
Alternative Names
CHEK2; checkpoint kinase 2; CHK2 (checkpoint, S.pombe) homolog , CHK2 checkpoint homolog (S. pombe) , RAD53; serine/threonine-protein kinase Chk2; bA444G7; CDS1; CHK2; HuCds1; PP1425; cds1 homolog; CHK2 checkpoint homolog; checkpoint-like protein CHK2; L
Product Background
Antigen Description
Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on Ser-216, preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at Thr-18 and Ser-20.
Pathway
Cell Cycle, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; FOXM1 transcription factor network, organism-specific biosystem; G1/S DNA Damage Checkpoints, organism-specific biosystem;
Citations
Publication ()
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COA
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