Anti-CDH1 (aa 381-480) polyclonal antibody

Species Reactivity

Human

Immunogen

CDH1 (ENSP00000261769, 381 a.a. ~ 480 a.a) partial recombinant protein with GST tag. The sequence is KGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAK GLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDV

Conjugate

Alternative Names

CDH1; cadherin 1, type 1, E-cadherin (epithelial); UVO; CDHE; ECAD; LCAM; Arc-1; CD324; cadherin-1; CAM 120/80; E-Cadherin; uvomorulin; cell-CAM 120/80; epithelial cadherin; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epitheli

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.

Pathway

Adaptive Immune System; Adherens junction; Apoptosis; Apoptotic cleavage of cellular proteins