Anti-CDH1 monoclonal antibody, clone N279

Antibody Isotype

IgG1

Clone

N279

Species Reactivity

Mouse; Rat; Horse; Human

Immunogen

Recombinant fragment containing amino acids in the C terminal region of Mouse E Cadherin. This sequence is highly conserved in human and rat E Cadherin.

Conjugate

Application Notes

Flow Cyt: 1/100; IHC-P: 5 μg/ml; WB: 1/1000; IP: 1/100; ELISA: 1/2000; ICC: 1/250.

Alternative Names

CDH1; cadherin 1; cadherin-1; ARC-1; E-cadherin; uvomorulin; epithelial cadherin; Um; UVO; Ecad; L-CAM; AA960649; MGC107495;

Entrez Gene ID

UniProt ID

Antigen Description

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

Pathway

Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Adherens junctions interactions, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cell adhesionproteins, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem;