Anti-CD47 (C-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide within Human CD47 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q08722

Conjugate

Application Notes

WB: 1/1000.

Alternative Names

CD47; CD47 molecule; CD47 antigen (Rh related antigen, integrin associated signal transducer); MER6; leukocyte surface antigen CD47; antigen identified by monoclonal 1D8; antigenic surface determinant protein OA3; CD47 glycoprotein; IAP; integrin associat

Entrez Gene ID

UniProt ID

Antigen Description

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

Pathway

Cell surface interactions at the vascular wall; Cell-Cell communication; ECM-receptor interaction; Hemostasis; Integrins in angiogenesis; Signal regulatory protein (SIRP) family interactions;