Anti-CD247 monoclonal antibody, clone 5E20B7

Antibody Isotype

IgG2a

Clone

5E20B7

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human CD247.

Conjugate

Application Notes

Immunohistochemistry (1:200-1:1000); ELISA (1:10000) & The optimal working dilution should be determined by the end user.

Alternative Names

CD247; CD247 molecule; CD3Z, CD3z antigen, zeta polypeptide (TiT3 complex) , CD247 antigen; T-cell surface glycoprotein CD3 zeta chain; CD3H; CD3Q; CD3zeta chain; TCR zeta chain; CD247 antigen, zeta subunit; T-cell receptor T3 zeta chain; CD3Z antigen, ze

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Pathway

Adaptive Immune System, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Disease, organism-specific biosystem; Downstream TCR signaling, organism-specific biosystem;