Rabbit Anti-Human CACNA2D2 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat

Immunogen

Synthetic peptide corresponding to internal residues of human CACNA2D2

Conjugate

Application Notes

IHC: 1:30-150

General Notes

This product (Catalog No. DPABH-25591) is a rabbit-derived polyclonal antibody raised against human CACNA2D2. This antibody exhibits cross-reactivity with CACNA2D2 from mouse and rat. It has been affinity purified by Protein A. Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.
DPABH-25591 is suitable for use in IHC (1:30–1:150) application.
DPABH-25591 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

CACNA2D

Entrez Gene ID

UniProt ID