Anti-CACNA2D2 (aa 65-162) polyclonal antibody

Species Reactivity

Human

Immunogen

CACNA2D2 (NP_006021, 65 a.a. ~ 162 a.a) partial recombinant protein with GST tag. The sequence is PQQHTMQHWARRLEQEVDGVMRIFGGVQQLREIYKDNRNLFEVQENEPQKLVEKVAGDIE SLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYY

Conjugate

Alternative Names

CACNA2D2; calcium channel, voltage-dependent, alpha 2/delta subunit 2; CACNA2D; voltage-dependent calcium channel subunit alpha-2/delta-2; gene 26; alpha 2 delta calcium channel subunit; voltage-gated calcium channel subunit alpha-2/delta-2;

Entrez Gene ID

UniProt ID

Antigen Description

Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.

Pathway

Adrenaline,noradrenaline inhibits insulin secretion; Arrhythmogenic right ventricular cardiomyopathy; Cardiac muscle contraction; Dilated cardiomyopathy