Anti-CACNA2D2 monoclonal antibody, clone FQS23454 Knockout Validated

Antibody Isotype

IgG

Clone

FQS23454

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment within Human CACNA2D2. The exact sequence is proprietary.Database link: Q9NY47

Conjugate

Application Notes

IP: 1/10 - 1/100; WB: 1/1000 - 1/10000.

Alternative Names

CACNA2D2; calcium channel, voltage-dependent, alpha 2/delta subunit 2; voltage-dependent calcium channel subunit alpha-2/delta-2; gene 26; KIAA0558; alpha 2 delta calcium channel subunit; voltage-gated calcium channel subunit alpha-2/delta-2; CACNA2D; LUA

Entrez Gene ID

UniProt ID

Antigen Description

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.

Pathway

Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem;