Anti-ATP1A1 monoclonal antibody, clone 470DU27.6.3

Antibody Isotype

IgM

Clone

470DU27.6.3

Species Reactivity

Mouse

Conjugate

Application Notes

WB: 1:1000-3200

Alternative Names

ATP1A1; Sodium/potassium-transporting ATPase subunit alpha-1; Sodium pump subunit alpha-1

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene belongs to the family ofP-type cation transport ATPases, and to the subfamily of Na+/K+-ATPases. Na+/K+ -ATPase is an integral membrane proteinresponsible for establishing and maintaining the electrochemicalgradients of Na and K ions across the plasma membrane. Thesegradients are essential for osmoregulation, for sodium-coupledtransport of a variety of organic and inorganic molecules, and forelectrical excitability of nerve and muscle. This enzyme iscomposed of two subunits, a large catalytic subunit (alpha) and asmaller glycoprotein subunit (beta). The catalytic subunit ofNa+/K+ -ATPase is encoded by multiple genes. This gene encodes analpha 1 subunit. Multiple transcript variants encoding differentisoforms have been found for this gene.

Pathway

Adrenergic signaling in cardiomyocytes; Aldosterone-regulated sodium reabsorption; Bile secretion; Carbohydrate digestion and absorption; Cardiac muscle contraction; Endocrine and other factor-regulated calcium reabsorption; Gastric acid secretion; Insulin secretion;