Specifications
Immunogen
Recombinant fragment within Human ATG4C aa 350 to the C-terminus. The exact sequence is proprietary.Database link: Q96DT6
Applications
Application Notes
WB: 1/10000 - 1/50000; IHC-P: 1/250; Flow Cyt: 1/100;
Target
Alternative Names
ATG4C; ATG4 autophagy related 4 homolog C (S. cerevisiae); APG4 autophagy 4 homolog C (S. cerevisiae) , APG4C, AUT (S. cerevisiae) like 1, cysteine endopeptidase; AUT like 1, cysteine endopeptidase (S. cerevisiae) , AUTL1; cysteine protease ATG4C; AUTL3;
Product Background
Antigen Description
Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Pathway
Regulation of autophagy, organism-specific biosystem; Regulation of autophagy, conserved biosystem;
Citations
Publication ()
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COA
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