Synthetic peptide corresponding to Human ATG4C aa 441-454 (C terminal) (Cysteine residue). (NP_835739.1).Sequence: EDEKKQLKRFSTEE Database link: Q96DT6
Conjugate
Unconjugated
Applications
Application Notes
WB: 2 - 6 μg/ml.
Target
Alternative Names
ATG4C; ATG4 autophagy related 4 homolog C (S. cerevisiae); APG4 autophagy 4 homolog C (S. cerevisiae); APG4C, AUT (S. cerevisiae) like 1, cysteine endopeptidase; AUT like 1, cysteine endopeptidase (S. cerevisiae); AUTL1; cysteine protease ATG4C; AUTL3; FL
Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Pathway
Regulation of autophagy;
Citations
Publication ()
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COA
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