Recombinant fragment corresponding to Human Activin A Receptor Type IB aa 154-415.Sequence: RVYHNRQ RLDMEDPSCE MCLSKDKTLQ DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT I
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/500 - 1/1000;
Target
Alternative Names
ACVR1B; activin A receptor, type IB; ALK4; SKR2; ACTRIB; ACVRLK4; activin receptor type-1B; activin receptor-like kinase 4; activin A receptor, type II-like kinase 4; serine/threonine-protein kinase receptor R2;
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2.
Pathway
Cytokine-cytokine receptor interaction; Developmental Biology; Regulation of signaling by NODAL; Signaling by Activin
Citations
Publication ()
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