Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
Synthetic peptide, corresponding to residues in the extracellular domain of Human Activin A Receptor Type IB.
Applications
Application Notes
WB: 1/1000 - 1/10000; IHC-P: 1/500 - 1/1000; Flow Cyt: 1/100 - 1/500; ICC/IF: 1/100 - 1/250;
Target
Alternative Names
ACVR1B; activin A receptor, type IB; ACVRLK4; activin receptor type-1B; ActRIB; ALK4; SKR2; activin receptor-like kinase 4; activin A receptor, type II-like kinase 4; serine/threonine-protein kinase receptor R2; ACTRIB;
Product Background
Antigen Description
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2.
Pathway
Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Developmental Biology, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; Regulation of Signaling by NODAL, organism-specific biosystem; Signaling by NODAL, organism-specific biosystem;
Citations
Publication ()
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COA
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