ACVR1B (AAH00254, 24 a.a. ~ 126 a.a) partial recombinant protein with GST tag. The sequence is SGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFY CLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVE
Conjugate
Unconjugated
Target
Alternative Names
ACVR1B; activin A receptor, type IB; ALK4; SKR2; ACTRIB; ACVRLK4; activin receptor type-1B; activin receptor-like kinase 4; activin A receptor, type II-like kinase 4; serine/threonine-protein kinase receptor R2;
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
Pathway
Cytokine-cytokine receptor interaction; MAPK signaling pathway; Signal Transduction; Signaling by NODAL
Citations
Publication ()
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